Coenzyme Q10 (CoQ10) is a fat-soluble compound required for mitochondrial ATP synthesis. CoQ10 functions as an antioxidant in cell membranes and lipoproteins (transport particles composed of lipids and protein). Tissue levels of CoQ10 decline with age and cholesterol-lowering medications decrease circulating levels of CoQ10. CoQ10 may provide nutritive support for optimal cardiovascular function by supporting healthy heart muscle function, normal blood pressure, and healthy endothelial function. Oral supplementation of CoQ10 is known to increase lipoprotein and blood levels and should be consumed with fat in a meal to maximize absorption.